Protein Details: 5-hydroxytryptamine receptor 3A

Protein ID

ICDB_Pro_0246

Protein Name

5-hydroxytryptamine receptor 3A

Gene Name

HTR3A; 5HT3R; HTR3

Organism

Cavia porcellus (Guinea pig)

Length

490 amino acids

AlphaFoldDB

AF-O70212-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes; which when activated cause fast; depolarizing responses in neurons.

Sequence

MVLWLQLALLALLLPTSLAQGEVRGKGTAQAHNSTRPALQRLSDHLLADYRKSVRPVRDWRKPTTVSIDAIVYAILSVDEKNQVLTTYIWYRQFWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDKSVFMNQGEWELLGVLTEFLEFSDRESRGSFAEMKFYVVIRRRPLFYAVTLLLPSIFLMIVDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLISVYFVVCMALLVISLAETILIVRLVHKQDLQQPVPLWLRHLVLERIAGLLCLGEQLTSHRGPATLQATKTDDFSGSTLLPAMGNHCGPLGGPQDLEKTSRGRGSPPPPPREASLAMCGLLQELASIRHFLEKREETREVARDWLRVGSVLDKLLFRVYLLAVLAYSITLVTLWSVWHYA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in cortex; intestine and liver. Not expressed in muscle or spleen.

DOI ID

10.1124/mol.53.2.202

RefSeq

NP_001166178.1 [O70212-1]

Feature